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Common Urologic Conditions

Caner Z. Dinlenc, MD
Harris M. Nagler, MD
Sovrin M. Shah, MD

KIDNEY STONES
URINARY TRACT INFECTIONS (UTI)
BENIGN PROSTATIC HYPERPLASIA (BPH)
URINARY INCONTINENCE
HEMATURIA

KIDNEY STONES
Hear Dr. Caner Dinlenc discuss how to prevent kidney stones.

The kidneys function as a filter for the body, removing waste products from the bloodstream and then removing them from the body in the form of urine. Kidney stones are a buildup of mineral waste deposits in the kidney not removed by urination. Stones can form for numerous reasons, such as an imbalance in the chemical composition of urine, inadequate fluid consumption, poor diet (one high in fats, sodium, sugars), blocked or restricted urine flow, or certain diseases (i.e., gout, colitis, arthritis).

Stones begin in the kidney and may either stay there or slowly pass down the ureter (the tube connecting the kidney to the bladder) to reach the bladder before passing through the urethra (the canal through which you urinate). Stones that are small and have a smooth exterior may show no symptoms and may pass unknowingly, but stones that are larger or have a rough exterior may lodge on their way out of the body.

Symptoms

  • Slight or severe pain when urinating
  • Blood in the urine (hematuria)
  • Pain in the kidney (flank), groin or abdomen
  • Recurrent urinary tract infections

Treatment
Patients with kidney stones have a number of options, with treatment depending on the size of the stone, its cause, and whether they are an isolated occurrence or recurring. In cases where it will not cause further complications, the stone is allowed to pass naturally by urination, and is collected for examination to determine its cause.

Other options for treatment are:

  • Changes in diet or fluid intake
  • Decreasing or increasing intake of certain vitamins
  • Medications
  • Extracorporeal Shock Wave Lithotripsy (ESWL), a non-surgical alternative to stone removal. Shockwave technology locates the stones and crushes or fragments them into fine particles. Patients may then pass the stone fragments naturally with little discomfort.
  • Minimally invasive surgery for unusually large stones that cannot be broken up by ESWL.

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URINARY TRACT INFECTIONS (UTI)
Often called cystitis which means inflammation of the bladder, urinary tract infections generally involve the bladder and rarely ascend (go upward) to involve the kidney where it is called pyelonephritis.

Symptoms

  • Frequent urination
  • Urgency (constant need to urinate)
  • Dysuria (pain when urinating)
  • Small volumes when urinating
  • Hematuria (blood in the urine)
  • Fever and/or flank/back pain

Causes and Treatments
The initial treatment for a urinary tract infection is antibiotics for 3-10 days, on average. If you have recurrent infections, treatment will depend upon the cause of the recurrent infections. There are multiple causes of UTI, depending on the age of the patient and/or their sex, with the primary causes listed below:

 
  • Sexual activity is the most common cause of recurrent urinary tract infections in the sexually active young female. Bacteria reside on the perineum (area between the rectum and vagina) and are introduced into the urethra/bladder during sexual intercourse. This type of infection is generally treated with antibiotics after sexual intercourse, and is called post coital prophylaxis.
   
 
  • Urethral diverticula develop in some women when a gland along the urethra becomes obstructed and swells. A small bulge can be felt vaginally coming from the urethra. During urination, this can fill with urine that may not empty. In addition, patients may have urinary frequency, dysuria (pain with urinating), and/or dyspareunia (pain with sexual intercourse). This condition is treated by surgical removal of the diverticula.
   
 
  • Menopause may lead to urinary tract infections because of the lack of estrogen. Local estrogen therapy restores the ability of the urethra to prevent ascent of bacteria into the urethra/bladder.
   
 
  • Stones, which can become infected and may continually infect urine in a descending (downward) way. These stones can be in the kidney, ureter or in the bladder. Stones are treated either medically or surgically depending on the composition of the stone and/or its location.
   
 
  • Retained Urine occurs if there is either an obstruction to urine flow or poor bladder contractility (weak bladder), leading to a retention of urine that can lead to a UTI. In men, obstruction may be due to urethral strictures or BPH (Benign Prostatic Hyperplasia). While rare, obstruction in women can be due to pelvic prolapse (dropped bladder or uterus) or urethral strictures. Poor bladder contractility may be due to Diabetes or neurologic conditions such as spinal cord injuries, stroke and/or Parkinson's Disease. In either case, patients may have symptoms of frequency (especially at night), straining to urinate, decreased force, and/or prolonged urination. Currently, the only treatment for retained urine due to poor bladder contractility is catheterization. These soft rubber catheters can either be used temporarily or permanently.

With patients that have retained urine because of obstruction, treatment is aimed at relieving the obstruction. Patients that have urethral strictures can have these dilated or incised. If the obstruction is due to BPH, patients may have TURP (trans-urethral resection of the prostate), TUNA (trans-urethral needle ablation of prostate), or open surgical procedures.

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BENIGN PROSTATIC HYPERPLASIA (BPH)
Benign Prostatic Hyperplasia, also called 'enlarged prostate' is generally found in men over the age of 50. In fact, nearly all men over the age of 50 have an enlarged prostate to some degree, but not all of these cases require treatment. The prostate is located under the bladder in men and behind the pubic bone. It partially surrounds the urethra and is responsible for many of the lower urinary tract problems experienced in men as it enlarges with age.

Symptoms

  • Frequency of urination, nocturia (frequency at night)
  • Urgency (desire to void again within a short time of urinating)
  • Hesitancy (waiting some time to initiate the stream)
  • Decreased force of urinary stream
  • Intermittency (a stop-start pattern in urinating)
  • Feeling of incomplete emptying (urine remaining in the bladder after urinating)

Diagnosis
On occasion, patients may develop similar symptoms due to prostatitis (inflammation of the prostate), primarily from infection that is treated with antibiotics. To determine if these symptoms are due to BPH, patients may be evaluated with:

 
  • DRE (digital rectal exam) is primarily done to rule out abnormalities of the prostate, such as cancer or prostatitis.
  • Urine studies (Urine Culture and Cytology) are done to rule out infection, hematuria (blood in the urine), glucosuria (sugar in the urine as can be seen in diabetics), and/or cancer.
  • Uroflow testing records the amount of urine voided, the speed (force) with which one urinates, the time needed to urinate, and will determine abnormalities in these areas. After uroflow testing is done, residual urine can be determined with a bladder scan, which is similar to an ultrasound of the bladder. If either of the two tests is abnormal, further evaluation with urodynamics (see below) is recommended.
  • AUA Symptom Sheet is used to determine the severity of your symptoms and to monitor treatment. This is a list of seven questions that incorporate much of the symptoms described above. Scored from 1-5, patients can receive a minimum score of seven (mild symptoms) or maximum score of 35 (severe symptoms).
  • Urodynamics determines bladder function with the aid of a computer. It is separated into 2 phases: a filling phase, and urinating phase. In the filling phase, the bladder is evaluated for involuntary contractions (overactive bladder), compliance (elasticity of the bladder), incontinence (involuntary loss of urine) and capacity (amount of fluid the bladder can comfortably hold). During urinating, bladder pressure is recorded to determine if it is normal, hypocontractile (weak) or obstructed (blocked). This test is generally done in the office and can take fifteen minutes.
  • Ultrasound is used to evaluate the kidneys for hydronephrosis (swelling) especially when there is residual urine found in the bladder either due to a hypocontractile bladder or obstruction from BPH. On occasion, a bladder ultrasound is done to evaluate prostate size, amount of residual urine and/or the presence of bladder stones.
  • Cystoscopy is performed to evaluate prostate size prior to or during treatment for BPH. This is an office procedure done with a local anesthetic. It not only evaluates the urethra for other causes of obstruction (i.e. strictures), it evaluates the prostate and more importantly the bladder. Many times a camera is placed on the cystoscope so that the patient can also see.

Treatment
Once it is determined that your symptoms are associated with BPH, treatment will depend on the severity of these symptoms. Treatments are either medical (non-surgical) or surgical.

 
  • Medical treatments include medications categorized as:
    Alpha Blockers, i.e. Flomax®, Cardura® (Doxazosin), and Hytrin® (Terazosin). Their action is aimed at the bladder neck (bladder opening) and prostatic urethra (area of the urethra surrounded by the prostate). By blocking the receptors that increase compression and closing of these channels, they allow for dilation and opening of the prostatic urethra and therefore a better flow of urine. Symptoms may improve within several days of starting the medication.

  • 5 Alpha Reductase Inhibitors, i.e., Proscar®. By blocking the 5 Alpha Reductase enzyme, the production of DHT (dihydrotestosterone) in the prostate is inhibited, therefore slowing or stopping growth. Many times this is used in combination with alpha blockers, and may take 3 to 6 months before prostate volume is notably decreased. In addition, PSA (prostate specific antigen) measured in the blood will be decreased by 50%. Therefore, it is important to alert your physician that you are on this medication if your PSA is being evaluated.

Surgical treatments for BPH vary from TURP (transurethral resection of the prostate), to minimally invasive procedures such as TUNA (Transurethral Needle Ablation), ILTT (Indigo Laser Thermotherapy), Microwave Therapy, WIT, or Prostatic Stents. While TURP removes tissue, the minimally invasive techniques employ the use of energy to heat the prostate, and time to allow the prostatic channel to open so that urinary flow is improved.

 
  • TURP (transurethral resection of the prostate) is the ‘gold standard’ by which all other surgical treatments of the prostate are compared to as it has had the best results. Done in a hospital setting with anesthesia, prostate tissue is resected (scraped) from within the urethra to create an open channel for one to urinate through. Afterwards, patients are placed on CBI (continuous bladder irrigation) to remove blood and clots that can form after the procedure. Generally a ‘voiding trial’ (removal of catheter to see if one can urinate) is performed about 1-2 days after the procedure.
  • TUNA (transurethral needle ablation) incorporates the use of radiofrequency energy delivered through two adjacent needles that are inserted into the prostatic tissue through the urethra. The treatment time is short and the procedure can be done with light sedation or local anesthesia in the office. Patients are sent home the same day with a catheter that is generally removed within seven days.
  • ILTT (Indigo Laser Thermotherapy) uses laser energy via a needle that is inserted into the prostatic tissue through the urethra. Generally done in an office setting, the procedure time is short and patients are generally sent home with a catheter that is removed after several days.
  • Microwave therapy is done either in the office or in the hospital with sedation. Using a urethral catheter, microwave energy is emitted to the area of the prostate over a period of about 45 minutes. Patients are sent home with a catheter for several days.
  • WIT is an office procedure that is done with local anesthesia. It uses the concepts of balloon dilation and hot water to treat the prostate. A urethral catheter is placed and a large balloon dilated in the prostatic area to push open the prostate. Then, heated water is circulated through the balloon to heat the prostatic tissue. Treatment time is generally 45 minutes and patients are sent home with a catheter that is removed after several days.
  • Prostatic Stents are devices placed in the prostatic urethra thereby compressing the obstructing prostate and creating an open channel to urinate through. They are generally used in patients that cannot tolerate any prolonged surgery.

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URINARY INCONTINENCE
Incontinence is defined as the involuntary loss of urine (i.e. leaking urine when one is not urinating). There are generally 4 different types of urinary incontinence:

  • Stress incontinence describes the loss of urine associated with ‘stress’ placed on the bladder and pelvic floor muscles such as exercise, coughing, laughing, sneezing and/or sexual intercourse.
  • Urge incontinence describes the loss of urine with a sudden desire to void that cannot be restrained. Fluid intake, spicy foods, infection, and/or any irritant in the bladder (i.e. stone, polyp) may initiate this.
  • Mixed incontinence incorporates aspects of both stress and urge as described above.
  • Overflow incontinence is seen in patients that have poorly contractile bladders (i.e. Diabetes, Neurologic disoders) or bladder outlet obstruction (BPH, urethral stricture, prolapse bladder/uterus)

Diagnosis
After a complete history and physical, there are many tests that are used to diagnose the type of incontinence, and how to treat it. These tests include:

  • Urine studies can be used to determine underlying conditions such as infections, hematuria, diabetes, or cancer.
  • Uroflow involves urinating into a computerized commode to determine the volume, speed and method of urinating.
  • Urodynamics documents bladder function and incontinence by using a computer to assess bladder activity while it is being filled and while one is urinating.
  • Cystoscopy to evaluate the bladder walls for possible polyps, stones or chronic infection.

Treatment
Using the above information, treatment for urinary incontinence may involve:

  • Behavior modification involves diet, fluid intake, voiding schedules, pelvic floor excercises/biofeedback for patients with stress, urge or mixed incontinence.
  • Medication is aimed at either the bladder (i.e. Detrol®, Ditropan®) or at the prostate (i.e. Flomax®, Hytrin® or Proscar® for patients with urge or overflow incontinence.
  • Surgery may be used to support the urethra/bladder for patients with stress incontinence (i.e. Pubovaginal Sling, TVT, Collagen injection) or to relieve the obstruction in patients with enlarged prostates (i.e. TURP, TUNA), urethral strictures or pelvic prolapse.
  • Catheterization may be used temporarily or permanently for patients with overflow incontinence who are either beginning medical therapy or awaiting surgery.

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HEMATURIA
Hematuria is defined as blood in the urine that is either seen or unseen (microscopic). When it is detected microscopically, it may be defined as trace, small, moderate or large depending on the number of red blood cells that are seen under the microscope.

There are many causes of hematuria, such as:

  • Urinary Tract Infections (UTI)
  • Kidney Stones- Movement of a kidney stone can irritate the lining of the kidney, ureter, bladder or urethra and cause hematuria. During movement of the stone, there may be flank pain.
  • Atrophic Vaginitis, which is seen in many women after menopause. Lack of local estrogen causes the vaginal/urethral tissues to be come dry and less flexible. Patients may complain of dyspareunia (pain with sexual intercourse). Lack of moisture causes the tissues to break easily, and bleeding can occur.
  • Renal Diseases, which can also be termed glomerulonephritis and include a host of medical conditions that effect the filtering properties of the kidney, such that red blood cells escape into the urine. Many times these conditions require no treatment, but other times medication is needed. Nephrologists (kidney specialists) are generally involved in evaluating and treating patients with the above findings.
  • Cancer that occurs in the kidney, ureter, bladder, prostate or urethra may cause hematuria either with or without pain.

Diagnosis
To determine the cause of hematuria, several tests are used:

  • Urine Culture is generally done at the time of the urinalysis to determine if there is an infection.
  • Urine Cytology is a urine test that looks at the shapes of the cells in the urine to determine if they are normal or abnormal, and is useful in detecting some cancers.
  • Renal Ultrasound is a non-invasive test done by a radiologist to evaluate the kidneys. By using an ultrasound probe that is pressed along the flank/back over the kidney, images of the kidney are seen. This can detect hydronephrosis (swelling), kidney stones, scarring (due to prior infections), or masses.
  • IVP (Intravenous Pyelogram) uses an iodine dye, given intravenously, in order to visualize the kidneys and ureters and determine their function. Patients that are allergic to iodine contrast or shellfish should alert their physician, as they may not be able to have this exam.
  • CT (CAT Scan) can be done with or without contrast. It is much faster than the IVP but does hold the same restriction to iodine contrast/shellfish allergies if using contrast.
  • Cystoscopy will evaluate the bladder walls for possible polyps, stones or chronic infection.

Treatment
Treatment will depend on the cause of the hematuria.

  • UTI will require antibiotics.
  • Kidney stones may require drug therapy, shock wave lithotripsy (used to break up the stone), or surgical removal.
  • Atrophic vaginitis is often times helped with local estrogen cream.
  • Renal disease is treated medically with close follow-up with a Nephrologist.
  • Cancer is treated surgically, depending on the organ affected.

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